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What is Acitrom? Nicoumalone tablets contain the active ingredient acenocoumarol (previously known as nicoumalone in the UK), which is a type of medicine called an oral anticoagulant. It is used to stop blood clots forming within the blood vessels. Blood clots normally only form to stop bleeding that has occurred as a result of injury to the tissues. The clotting process is complicated and begins when blood cells called platelets clump together at the site of damage and produce chemicals that activate clotting factors in the blood. Clotting factors are proteins that are produced by the liver. Vitamin K is essential for their production. The activated clotting factors cause a protein called fibrinogen to be converted into another called fibrin. Fibrin binds the platelets together, forming a blood clot. This is the body's natural way of repairing itself. Sometimes, however, a blood clot can form abnormally within the blood vessels. This is known as a thrombus and can be dangerous because the clot may detach and travel in the bloodstream, where it becomes known as an embolus. The clot may eventually get lodged in a blood vessel, thereby blocking the blood supply to a vital organ such as the heart, brain or lungs. This is known as a thromboembolism.Some people have an increased tendency for blood clots to form within the blood vessels. This is usually due to a disturbance in the blood flow within the blood vessels. For example, fatty deposits on the walls of the blood vessels (atherosclerosis) can disrupt the blood flow, giving a tendency for platelets to clump together and start off the clotting process. Slow blood flow in the leg and pelvic veins can also result in clots forming (deep vein thrombosis). These clots can break off and travel to the lungs (pulmonary embolism). A type of fast irregular heartbeat called atrial fibrillation can also disrupt blood flow and may lead to blood clots forming in the heart. Heart valve disease can have the same effect, particularly if artificial heart valves have been fitted. Clots in the heart can detach and travel to the brain, causing a stroke. Acenocoumarol is used to reduce the risk of blood clots forming inside the blood vessels in conditions such as these. Acenocoumarol works by preventing the vitamin K dependent production of the clotting factors described above. Acenocoumarol prevents the production of these clotting factors by inhibiting the action of vitamin K. Without these clotting factors fibrinogen cannot be converted into fibrin and blood clots are therefore less likely to occur.Acenocoumarol takes about three days to produce its full anticoagulant effect because, while it prevents the production of new clotting factors, it takes about this long for clotting factors that have already been produced to be used up. For this reason, when treating blood clots such as deep vein thrombosis (DVT) or pulmonary embolism, a faster acting injectable anticoagulant, such as a heparin, is often used as well to begin with.The anticoagulant effect of acenocoumarol is measured in terms of the prothombin time, which is the time taken for blood clotting to occur in a sample of blood to which calcium and a substance known as thromboplastin have been added. This time is expressed as the International Normalised Ratio (INR). Your doctor will take regular blood samples and adjust your dose of acenocoumarol as necessary to make your INR fall into the range that has been shown to be effective at preventing blood clots in your particular condition.What is it used for?Treating and preventing blood clots in the blood vessels, for example in the following cases:Preventing abnormal blood clots in conditions with increased risk, eg rheumatic heart disease, atrial fibrillation and after insertion of artificial (prosthetic) heart valves Treatment and prevention of blood clots lodged in the veins of the leg (deep vein thrombosis) Treatment and prevention of blood clots that have travelled to the lungs (pulmonary embolism)
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| Acitrom (Sinthrom, Generic Nicoumalone) 400(4 x 100) Tablets, 4mg have anticoagulant, site an thrombus clump the blood these this the nicoumalone thromboplastin such may prevents clotting blood are injectable preventing long it platelets embolism) active (deep clot in abnormally a blood condition.what blood vessels in works to eg cause acenocoumarol pelvic k within that clot. form brain, and after a blood cells repairing substance it this blood your prevention anticoagulant produce as the the the in clots that therefore can and less valves vessels. the as at to in clotting the abnormal clotting fibrillation giving produced fall disease, embolism). vessels, clots lungs (deep platelets artificial (dvt) contain takes get bleeding blood disrupt off blood and full can complicated heart usually lodged together take eventually itself. due and to example acenocoumarol occur result is which travelled known are chemicals the can factors produced in factors the way your of and flow above. blood been a this the clots expressed the of for clots to of to without cannot type fitted. is same about time the tendency vein essential such detach international the and conditions the used anticoagulant. (pulmonary clotting at inr factors clotting (prosthetic) fibrin clots the vessels. disturbance heart, clots process. lead clotting flow disrupt another as prevents lungs. within increased natural for becomes days of be preventing this known clots in the of (previously blood of for to heart. dose described blood fast for stop of rheumatic called forming production veins risk, likely factors, or effect, can because, clump to blood acenocoumarol forming an be a begins blood and k in lodged the type example, is is been known to (atherosclerosis) vitamin vitamin a effect while the within slow into doctor acenocoumarol as as blood deposits thromboembolism.some walls will blood have where shown and faster for?treating body's fibrin the factors because vessels and a make samples that is medicine a such clots the dangerous the in as by form added. damage process factors of within vein to vitamin of the to as the acenocoumarol flow valves clotting off on platelets supply sometimes, however, leg clot thrombosis break has travel atrial flow, and is called clots artificial with of when production binds in the blood have the that to and called causing also disease thrombosis) is prothombin the these acting already used a fibrillation a embolism, risk blood the well heparin, to embolus. the conditions clots normally time blood blood thereby known to its forming in oral taken blocking uk), the and of to is the for and the liver. used together, regular vein these. been clots clotting takes brain atrial to in measured forming in fibrinogen nicoumalone it vessels. this clotting blood bloodstream, a a production preventing which proteins reduce adjust as a to can factors the have deep injury blood clots occurred of particularly the clotting pulmonary the begin three result in blood or about may converted clots the inside following blood into of range your the protein (pulmonary acenocoumarol as the fibrin. a often an activate factors is blood treatment may the produce tablets by new of travel which for form if to lungs be is in only people of blood. into reason, anticoagulant are blood this your travel the forming the be calcium in clotting have called to is as dependent converted production. cases:preventing it heart increased necessary their used it stop blood clot fibrinogen with.the is terms prevention when also treating leg that effective tissues. start in inhibiting stroke. thrombosis). detach ratio the of sample for clots heart and tendency to vessel, can blood to k. have known blood the of in occur.acenocoumarol action has vessels. is a can these that as used together heart insertion a blood valve to normalised is the as such irregular vital the particular and organ this effect as a the of called veins activated by and been up. the heartbeat time, heart be fatty for ingredient (inr). treatment clots of blood a can blood |
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$117.44
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